| Drug-Exercise Interaction: A mini review on Orlistat |
| Paper ID : 1015-SPORTCONGRESS (R1) |
| Authors |
|
Marzieh-beygom Siahpoosh * Persian Medicine Association |
| Abstract |
| Introduction: Orlistat, as a drug in the treatment of obesity, acts by reversibly inhibiting gastric and pancreatic lipases so orlistat inhibits dietary fat absorption however, it has beneficial consequence on carbohydrate metabolism. More than 99% of the drug is bound to the plasma proteins specially lipoproteins and albumin. Hypertension, Malaise, and Nephropathy (Lower leg oedema) reported as some drug side effects. Since the role of exercise in the treatment of obesity is known and many obese patients tend to use medication along with diet and exercise, and according to recent researches, some medications interfere with exercise, this study investigated the interaction between orlistat use and exercise. Methods: Searching valid scientific databases with keywords, selection of articles, and extracting relevant content is the method of conducting the study. Results: According to studies, there are some relations between exercise and using orlistat: A. The maximum benefit of orlistat occurs when used in conjunction with diet and exercise B. Despite the reduction of vitamin A and E levels, orlistat does not increase the level of oxidative stress, but when it is combined with exercise, the level of oxidative stress is significantly reduced. C. Aerobic exercise and taking Orlistat reduce the body's energy reserves and increased levels of acylated ghrelin secretion, resulting in stimulation of food intake and energy balance Conclusion: In particular, no studies on drug-exercise interactions were found for orlistat. Existing studies have not addressed the time interval between orlistat use and exercise and have not reported any complications. If the drug binds to plasma proteins and if it can increase blood pressure and cause lower limb edema by acting on the kidney, there is a possibility that it may interfere with exercise, so the interval between drug intake and exercise and maybe the type of exercise should be carefully studied when taking this drug. |
| Keywords |
| Orlistat, Drug-exercise interaction, Obesity |
| Status: Abstract Accepted (Poster Presentation) |
