| The Effect of Eight Weeks of Resistance Training With Probiotic Supplementation on Brain-Derived Neurotrophic Factor(BDNF) level and Spatial Memory In Ovariectomized Rats |
| Paper ID : 1019-SPORTCONGRESS (R1) |
| Authors |
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فرشته افتخاری *1, Fatemeh Rahimi2, Farhad Daryanoosh3 1استادیار بخش علوم ورزشی، دانشکده علوم تربیتی و روانشناسی، دانشگاه شیراز، شیراز، ایران 2Department of Sports Sciences, faculty of Education and psychology, University of Shiraz 3Department of Sports Sciences, faculty of Education and psychology, University of Shiraz |
| Abstract |
| Recent studies have highlighted the role of probiotics in brain health. In this regard, the present study was aimed at determining the effect of probiotic supplementation along with resistance training on Brain-Derived Neurotrophic Factor and Spatial Memory in ovariectomized Rats. 48 female rats (age: 10-12 weeks, breed: Wistar) were divided into 6 groups (N=8) control, sham, immobilized surgery, surgery+supplement, surgery+exercise, surgery +supplements+exercise were divided. Resistance training was done during eight weeks, one day in between. Daily, one gram of probiotic supplement was dissolved in distilled water to a volume of 20 ml, and the target rat received one ml of it by gavage. Spatial memory was measured using Morris blue maze and brain derived neurotrophic factor (BDNF) by ELISA method. One-way analysis of variance was used to determine the overall difference between groups, and Bonferroni's post hoc test was used to determine the exact location of the difference between groups. Also, in order to determine the relationship between research variables, Pearson's correlation coefficient was used (P<0.05). A significant increase in BDNF in the surgery+supplements+exercise group compared to other intervention groups (P=0.001) and a significant decrease in spatial memory in the said group compared to other interventions (P=0.001) were observed. Also, there was a negative and significant correlation between BDNF and spatial memory variables (p=0.001, r=-0.929). In general, it seems that probiotic supplements and exercise complement each other and have a synergistic effect to increase BDNF and improve spatial memory. |
| Keywords |
| Resistance Training, Spatial Memory, Ovariectomized Rats, Brain-Derived Neurotrophic Factor (BDNF), Probiotic Supplement. |
| Status: Abstract Accepted (Poster Presentation) |
