| THE EFFECT OF AEROBIC, RESISTANCE, AND COMBINED TRAINING ON IL-6 AND TNF-Α IN ELDERLY ADULTS: A SYSTEMATIC REVIEW AND META-ANALYSIS |
| Paper ID : 1112-SPORTCONGRESS |
| Authors |
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Reihaneh Jafari, Fatemeh Dehghani, Ali Sayeh aftabi, Mousa Khalafi * Department of Sport Science, Faculty of Humanities, University of Kashan |
| Abstract |
| Introduction: Aging is often accompanied by a state of chronic low-grade inflammation, which significantly contributes to the development of sarcopenia—an age-related loss of muscle mass and function. Exercise training has been proposed as an effective strategy to prevent sarcopenia by mitigating systemic inflammation, thereby representing a promising intervention to improve health outcomes in older adults. Accordingly, we conducted a systematic review and meta-analysis to evaluate the effects of exercise training on key inflammatory markers, including interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), in older adults aged 65 years and above. Methods: A comprehensive search was performed in PubMed and Web of Science databases up to December 2021. Keywords such as “exercise,” “inflammatory markers,” “elderly,” and “randomized controlled trial” were used to identify eligible randomized controlled trials (RCTs) that compared exercise interventions to control conditions and reported outcomes on IL-6 and TNF-α in populations with a mean age ≥65 years. Data were pooled using random-effects meta-analysis to calculate standardized mean differences (SMDs) with corresponding 95% confidence intervals (CIs) to assess the effect sizes of exercise training on inflammatory markers. Results: The results shown a significant decrease in IL-6 following combined training (SMD: − 0.26, p = 0.04), but not aerobic (SMD: − 0.24, p = 0.20), or resistance (SMD: − 0.12, p = 0.28) training. For TNF-α, a significant decrease occurred following aerobic training (SMD: − 0.44, p = 0.009), but not resistance (SMD: − 0.25, p = 0.06), or combined (SMD: − 0.26, p = 0.09) training. Conclusion: The current meta-analysis highlights that combined training is effective in reducing IL-6 levels, while aerobic training appears to be the most effective approach for lowering TNF-α in elderly adults. |
| Keywords |
| Exercise, Inflammation, Cytokine, Elderly |
| Status: Abstract Accepted (Poster Presentation) |
