| Study of types of exercise on serum interleukin 17 levels in male Wistar rats with Alzheimer's disease |
| Paper ID : 1143-SPORTCONGRESS |
| Authors |
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Sahar Seyed Soltani *1, Ameneh Pourrahim Ghouroghchi2 1Department of Physical Education and Sport Sciences, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, IRAN. 2Department of Physical Education and Sport Sciences, Faculty of Educational Sciences and Psychology, , University of Mohaghegh Ardabili, Ardabil, IRAN. |
| Abstract |
| Introduction: Alzheimer’s disease (AD), the leading cause of age-related dementia, involves memory loss, cognitive decline, and neuroinflammation. In this regard, endurance, resistance and combined exercises can have different effects on inflammatory factors and markers associated with Alzheimer's disease. Endurance training improves cardiovascular function, increases cerebral blood flow and reduces systemic inflammation. This type of exercise can reduce the level of amyloid beta, which is a key factor in the accumulation of destructive brain plaques in Alzheimer's patients (1). Also, endurance training may help reduce phosphorylated tau protein, which is another sign of neurodegeneration in Alzheimer's. On the other hand, these exercises can reduce the level of interleukin 17 (IL-17), a pro-inflammatory cytokine associated with the progression of neurodegenerative diseases, by modulating the immune system (2, 3). This study examined how eight weeks of endurance, resistance, and combined exercise affect serum Interleukin-17 (IL-17) levels in male Wistar rats with induced AD. Methods: Forty male Wistar rats were randomly divided into five groups: Control, Alzheimer (ALZ), Endurance+ALZ, Resistance+ALZ, and Combined+ALZ. Alzheimer’s disease was induced using Trimethyltin chloride (TMT). Training protocols were conducted over eight weeks. Serum IL-17 levels were measured using ELISA, and data were analyzed via one-way ANOVA and Tukey’s post-hoc test (P<0.05). Results: IL-17 levels were significantly elevated in the ALZ group compared to the Control. While exercise groups showed a reduction in IL-17 levels compared to the ALZ group, the combined exercise group exhibited the most substantial decrease. However, significant differences were not observed between ALZ and individual endurance or resistance training groups. Conclusion: Eight weeks of exercise training, particularly the combined protocol, may mitigate neuroinflammation through IL-17 modulation in Alzheimer’s disease models. These findings support the potential of combined physical activity as a therapeutic strategy to delay or reduce neurodegenerative processes in AD. |
| Keywords |
| Alzheimer’s disease, Exercise training, Interleukin-17 (IL-17), Neuroinflammation |
| Status: Abstract Accepted (Poster Presentation) |
