| EFFECTS OF EIGHT-WEEK PROGRESSIVE RESISTANCE TRAINING ON SERUM INFLAMMATORY MARKERS IN WOMEN WITH POLYCYSTIC OVARY SYNDROME |
| Paper ID : 1168-SPORTCONGRESS (R1) |
| Authors |
|
masome nobahar * Assistant professor of physical education, Payame Noor university, Tehran, Iran , |
| Abstract |
| Introduction: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in reproductive-aged women, characterized by hormonal imbalance, insulin resistance, and chronic low-grade inflammation (Diamanti-Kandarakis & Dunaif, 2012). Elevated inflammatory biomarkers such as C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) are commonly observed in women with PCOS and contribute to the progression of metabolic and cardiovascular complications (Escobar-Morreale, Luque-Ramírez, & González, 2011). Resistance training (RT) has been identified as a non-pharmacological strategy capable of improving insulin sensitivity and modulating systemic inflammation through reductions in inflammatory cytokines and enhancement of anti-inflammatory myokines (Pedersen & Febbraio, 2012). Recent systematic reviews have shown that structured exercise programs can reduce inflammatory markers and improve metabolic function in PCOS populations (Wang et al., 2023; Moori et al., 2023).The present study aimed to examine the effects of an eight-week progressive RT program on serum levels of CRP, IL-6, and TNF-α in women with PCOS. Methods: Thirty women aged 19–33 years, meeting the Rotterdam diagnostic criteria for PCOS, were randomly assigned to either an intervention (n = 15) or control group (n = 15). The RT group performed three sessions per week, starting at 40% of one-repetition maximum (1RM) and increasing by 5% weekly, targeting major muscle groups. Serum inflammatory markers were assessed before and after intervention using enzyme-linked immunosorbent assay (ELISA) kits . Results: Results showed significant reductions in CRP (–32.8%), IL-6 (–29.5%), and TNF-α (–27.3%) in the RT group compared with controls (p < 0.05). Conclusion: These findings suggest that RT effectively decreases systemic inflammation, possibly via suppression of NF-κB signaling and improved insulin sensitivity. In conclusion, eight weeks of progressive resistance training may serve as a safe and effective non-pharmacological strategy to attenuate inflammation in women with PCOS (Wang et al., 2023; Pedersen & Febbraio, 2012). |
| Keywords |
| Polycystic ovary syndrome, Resistance training, Inflammatory biomarkers, CRP, IL-6, TNF-α |
| Status: Abstract Accepted (Poster Presentation) |
