| The Effects of Intermittent Fasting on Inflammatory Markers in Adults: A Systematic Review and Pairwise and Network Meta-Analyses |
| Paper ID : 1247-SPORTCONGRESS |
| Authors |
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Mohammad Sadegh Tarashi1, Mousa Khalafi2, Aref Habibi Maleki3, Shima Mojtahedi4, Mahsa Ehsanifar5, Sara K. Rosenkranz6, Michael E. Symonds7, سعید فتح الهی *8, Maria Luz Fernandez9 1Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran 1417935840, Iran; 2Department of Sport Sciences, Faculty of Humanities, University of Kashan, Kashan 87317-53153, Iran 3Physiology Research Center, Iran University of Medical Sciences, Tehran 14496-14535, Iran; 4Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran 1417935840, Iran 5Department of Exercise Physiology and Corrective Exercises, Faculty of Sport Sciences, Urmia University, Urmia 5756151818 6Department of Kinesiology and Nutrition Sciences, University of Nevada Las Vegas, Las Vegas, NV 89154, USA 7Centre for Perinatal Research, Academic Unit of Population and Lifespan Sciences, School of Medicine, University of Nottingham, Nottingham NG7 2QL, UK 8Department of Physical Education and Sport Sciences, Faculty of Humanities, Tarbiat Modares University, Tehran 111-14115, Iran 9Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA |
| Abstract |
| Introduction:Intermittent fasting (IF) can improve inflammatory status, but its effects may be dependent on the mode of fasting. Objectives: We performed a systematic review with pairwise and network meta-analyses to investigate the effects of different modes of IF on inflammatory markers in adults. Methods: Three database searches were conducted, including PubMed, Scopus, and Web of Science, from inception to June 2024. The searches used two keyword groups: “intermittent fasting” and “inflammatory markers”. Randomized and non-randomized trials investigating any IF mode on inflammatory markers, including interleukin (IL)-6, tumor necrosis factor (TNF)α, C-reactive protein (CRP), leptin, and adiponectin, were included. Standardized mean differences (SMDs) were calculated using random effects models for both analyses. Results: A total of 21 studies (839 participants) were included. Compared with controls, IF reduced TNF-α [SMD: −0.31, p = 0.009], CRP [SMD: −0.19, p = 0.04], and leptin [SMD: −0.57, p = 0.005] but did not significantly affect IL-6 or adiponectin. Among the IF modes, time-restricted feeding (TRF) showed the largest reduction in TNF-α [−0.39, p = 0.001]. TRF had the highest probability ranking for changes in IL-6, TNF-α, leptin, and adiponectin; however, the effects on IL-6 and adiponectin were not statistically significant. The 5:2 diet ranked highest for CRP. Conclusion: IF may be an effective dietary therapy for improving some inflammatory markers, with effects potentially influenced by the mode of IF. TRF had the highest rankings across multiple markers, though the findings were not uniformly significant. Additional longer-term trials are needed to fully elucidate the anti-inflammatory potential of IF. Keywords: intermittent fasting; adipokine; cytokine; CRP |
| Keywords |
| intermittent fasting; adipokine; cytokine; CRP |
| Status: Abstract Accepted (Poster Presentation) |
