| Interaction of Vit D supplementation and High Intensity Interval Training on Interleukin 1 beta . beta catenin inflammation system variables in heart tissue of middle-aged Wistar rats |
| Paper ID : 1304-SPORTCONGRESS |
| Authors |
|
parnia sarikhani * Department of Exercise Physiology, Faculty of Exercise Sciences, Kharazmi University, Tehran, Iran |
| Abstract |
| Inflammation is a critical factor in cardiovascular diseases and both interleukin-1β (IL-1β) and β-catenin are important regulators of cardiac myocyte functions. The study investigates the impact of vitamin D supplementation and high-intensity interval training (HIIT) on IL-1β and β-catenin gene expression in heart tissue as well as maximal oxygen consumption (VO2max) in middle-aged male Wistar rats. Twenty-two 12-month-old male Wistar rats (250–300 g) were purchased from the Pasteur Institute of Iran. The rats were randomly divided into four groups: control, vitamin D, HIIT and HIIT + vitamin D. The protocol comprised a 5-minute warm-up at 50% VO2max, interval running with active rest and a 5-minute cool-down at 40% VO2max. The vitamin D (500 IU/kg) was dissolved in 1 mL of olive oil and administered using oral gavage three times a week for a week. The synergistic effect of exercise and vitamin D significantly altered the gene expression of IL-1β and β-catenin in cardiac tissue and enhanced VO2max. Significantly lower IL-1β levels in vitamin D, HIIT and combination groups than control demonstrated decreased cardiac inflammation. The more β-catenin level in the HIIT and combined groups than in the control group and, in the combined group, than vitamin D and HIIT alone means that cardiac cell adhesion is better, indicating better physiological hypertrophy. Moreover, VO2max significantly increased in HIIT, vitamin D and combined groups compared to control and in HIIT and combined compared to the vitamin D group , indicating better cardiovascular capacity and oxygen delivery to body organs. This study suggests that the combination of HIIT and vitamin D supplementation might offer considerable benefits for alleviating cardiac inflammation, improving heart health and boosting aerobic capacity in aged subjects. |
| Keywords |
| heart tissue, beta-catenin, interleukin-1β, vitamin D high-intensity interval training |
| Status: Abstract Accepted (Poster Presentation) |
