SYNERGISTIC EFFECTS OF TAURINE SUPPLEMENTATION AND COMBINED TRAINING ON ADIPOKINES IN MEN WITH OBESITY

Paper ID : 1320-SPORTCONGRESS

Authors

Ali Tavakoli *, Shima Mojtahedi دانشگاه تهران

Abstract

Introduction: Obesity is associated with chronic low-grade inflammation, and increased risk of comorbidities such as cardiovascular diseases and type 2 diabetes. Taurine (TAU) has demonstrated anti-inflammatory and metabolic benefits, while exercise, particularly combinations of aerobic and resistance training (CT), is an established intervention for improving metabolic health. However, effects of simultaneous combination of taurine supplementation and CT on adipokines in obese men remain unclear. This study aimed to investigate combined effects of taurine supplementation and combined training on adipokines (leptin, adiponectin) in men with obesity. Methods: A randomized controlled trial was conducted on 40 men with obesity (BMI ≥30 kg/m²), randomly allocated to one of four intervention groups: taurine + combined training (TAU + CT), taurine supplementation only (TAU), combined training only (CT), or a control group (CON). During the 8-week interventions, participants completed supervised training sessions three times per week. Taurine groups consumed 3 g/day of taurine in capsule form. Pre- and post-intervention assessments included body composition analysis via bioelectrical impedance analysis (BIA) , and venous samples were used to determine adipokines . Primary outcomes were analyzed using ANCOVA with Bonferroni post hoc tests.. Results: In the TAU + CT group, leptin decreased and adiponectin increased significantly more than either TAU or CT alone. Additionally, TAU + CT and CT groups experienced significant reductions compared to the control group in waist circumference and fat mass, although no significant differences were observed in total body weight or fat-free mass. Conclusion: The combination of TAU and CT significantly improved inflammatory markers compared to CON and enhanced adipokines compared to either TAU or CT alone, highlighting a potential synergistic effect. These findings suggest combining TAU supplementation with structured CT may be an effective strategy for improving metabolic health in individuals with obesity. Future studies should explore long-term effects and biological sex-specific responses.

Keywords

Combined training, Taurine, Adipokines, Obesity, Cytokines, Amino acids

Status: Abstract Accepted (Poster Presentation)