| Synergistic Effects of Taurine Supplementation and Combined Training on Inflammatory Cytokines in Men with Obesity |
| Paper ID : 1321-SPORTCONGRESS |
| Authors |
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Ali Tavakoli *1, Shima Mojtahedi1, Ramin Rafiei2, Selin Mrzaeian2 1دانشگاه تهران 2Faculty of sport sciences and health,15th street, norhth karger, Tahran, IRAN |
| Abstract |
| Introduction: Obesity is associated with chronic low-grade inflammation. Taurine (TAU) has demonstrated anti-inflammatory and metabolic benefits, while exercise training, particularly combinations of aerobic and resistance training (CT), is an established intervention for improving metabolic health. However, effects of simultaneous combination of taurine supplementation and CT on inflammatory markers and adipokines in individuals with obesity remain unclear. This study aimed to investigate the independent and combined effects of taurine supplementation and combined training on inflammatory cytokines (IL-6, IL-10, IL-15, TNF-α) in men with obesity. Methods: A randomized controlled trial was conducted on 40 men with obesity (BMI ≥30 kg/m²), randomly allocated to one of four intervention groups: taurine + combined training (TAU + CT), taurine supplementation only (TAU), combined training only (CT), or a control group (CON). During the 8-week interventions, participants completed supervised training sessions three times per week. Taurine groups consumed 3 g/day of taurine in capsule form. Pre- and post-intervention assessments included body composition analysis via bioelectrical impedance analysis (BIA) , and venous samples were used to determine inflammatory cytokines and adipokines . Primary outcomes were analyzed using ANCOVA with Bonferroni post hoc tests.. Results: From pre-to post-intervention, the TAU + CT group had significantly larger reductions in IL-6 and TNF-α and increases in IL-10 and IL-15 levels as compared to the control group (p < 0.05). Additionally, TAU + CT and CT groups experienced significant reductions compared to the control group in waist circumference and fat mass, although no significant differences were observed in total body weight or fat-free mass. Conclusion: The combination of TAU and CT significantly improved inflammatory markers compared to CON. These findings suggest that combining TAU supplementation with structured CT may be an effective strategy for improving metabolic health in individuals with obesity. Future studies should explore long-term effects and biological sex-specific responses. |
| Keywords |
| Combined training, Taurine, Inflammatory markers, Obesity, Cytokines, Amino acids |
| Status: Abstract Accepted (Poster Presentation) |
