| Studying the Changes of C-reactive Protein Level in Response to Exercise Training and Saffron Supplementation: A Systematic Review and Meta-analysis |
| Paper ID : 1329-SPORTCONGRESS |
| Authors |
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Yazgaldi Nazari *1, Araz Nazari2 1Department of sports sciences, Faculty of Humanities and social sciences, Golestan University, Gorgan, Iran 2Department of physical education, University of Saravan, Saravan, Iran |
| Abstract |
| Introduction: Exercise affects the inflammatory factors, and medicinal plants play an important role in reducing these indicators. Saffron supplementation has been considered by researchers as a nutritional solution for modulating inflammation caused by exercise training. Therefore, the purpose of this study was to investigate the the changes of c-reactive protein level in response to exercise training and saffron supplementation through a systematic review and meta-analysis. Methods: The present study was carried out based on the Cochrane guidelines and the Preferred Items in the Reporting of Systematic Reviews and Meta-Analysis (PRISMA) articles. A systematic search of articles published in English and Persian was conducted from the databases Scopus, Science Direct, PubMed, Web of Science, SID, and Magiran until August 2025 and entered into meta-analysis. . Fixed and random effect models for meta-analysis of average effect size (difference in mean with 95% confidence interval) in the research related to C-reactive Protein was performed with the help of CMA2 software. The I2 index was also used to determine the heterogeneity of studies, and publication bias was examined using funnel plot analysis and Egger's test.. Results: In investigating the effect of exercise training and saffron suplemantation on C-reactive Protein, 6 studies were entered into the CMA software. The results of meta-analysis showed that exercise training and saffron supplementation does not cause significant changes in C-reactive Protein (ES=-0.419, p=0.38, 95% CI= -1.35 to 0.517). Conclusion: Exercise training with saffron supplementation prevents the increase in C-reactive protein, that indicating the anti-inflammatory role of saffron. |
| Keywords |
| C-reactive protein, Saffron extract, Training. |
| Status: Abstract Accepted (Poster Presentation) |
