| Effects of tryptophan supplement with aerobic training on visceral adipose tissue inflammation and insulin resistance in aging rats |
| Paper ID : 1332-SPORTCONGRESS |
| Authors |
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Malihe Najafi *1, Parvaneh Nazarali1, Rostam Alizadeh2, Najmeh .Rezaeinezhad3 1Department of Exercise Physiology, Faculty of Sport sciences, University of Alzahra,Tehran,Iran 2. Department of Exercise Physiology,Sport Sciences Research Institute,Tehran,Iran 3. Department of Exercise Physiology, Faculty of Sport sciences and Health, University of Tehran,Tehran,Iran |
| Abstract |
| Abstract Introduction: This study was aimed at evaluating the effects of combining aerobic interval training and tryptophan supplementation on tumor necrosis factor alpha (TNF-α) levels in visceral adipose tissue and insulin resistance in high-fat diet (HFD) fed rats Methods: To this end, 32 aged rats (24 weeks old) were divided into five groups including normal diet sedentary, HFD sedentary, HFD+aerobic training, HFD+ tryptophan, HFD+aerobic training+tryptophan. Aerobic interval training was included 3 times a week for 8 weeks. Rats were consumed 100 mg/kg body weight of tryptophan daily. 24 hours after the last training session, after anesthesia, the adipose tissue was dissected and used for analyzing TNF-α by using elisa kit. The results showed that HFD had no significant effect on body weight, visceral fat mass, insulin, glucose, insulin resistance and TNF-α level. Results: The results showed that there were no significant effects of HFD on serum glucose and insulin, adipose tissue TNF-α and systemic insulin resistance compared to the normal diet. However, tryptophan supplementation significantly decreased TNF-α level in adipose tissue but had no significant effects of serum insulin and glucose and systemic insulin resistance. On the other hand, aerobic interval training decreased glucose and insulin resistance but had no significant effect on systemic insulin resistance and TNF-α level in adipose tissue. Furthermore, no significant effects of tryptophan and exercise intraction on these variables were seen Conclusion: . Overall, this study suggests that tryptophan supplementation decreased adipose tissue inflammation and exercise training decreased insulin resistance in aged rats. |
| Keywords |
| Aerobic Training, Essensial Amino Acids, Obesity, Glucose Metabolism, Diabetes, Aging |
| Status: Abstract Accepted (Poster Presentation) |
