combined training and cellular signaling responses in skeletal muscle: A systematic review

Paper ID : 1350-SPORTCONGRESS

Authors

Morteza Sangdevini * عضو هیأت علمی

Abstract

Introduction: Resistance training specifically activates the Akt–mTOR–p70S6K pathway, leading to increased protein synthesis and endurance training stimulates metabolic pathways including AMPK–PGC-1α and mitochondrial biogenesis. combined training (CT) with both types of training simultaneously can create synergy, but there is also the possibility of an interference effect that may limit protein synthesis. This systematic review aims to summarize the literature on the effects of concurrent training on cellular signaling responses in skeletal muscle. Methods: A systematic literature search was conducted according to the PRISMA. Searches were performed in PubMed, Scopus, Web of Science, SID, and Civilica, including human and animal studies. Of the 485 articles found, 37 eligible studies were finally included in the analysis. Results: The results showed that combined training causes activation of the AMPK and PGC-1α pathways (related to mitochondria and energy metabolism) and partial inhibition of the mTOR pathway (related to protein synthesis). The interference effect between endurance and resistance training depends on the intensity, order of execution, and intervals between training sessions. Conclusion: In general, combined training induces simultaneous adaptations in strength and endurance by balancing anabolic and oxidative pathways. However, temporal differences in activation of signaling pathways and the lack of human studies are still important limitations.

Keywords

concurrent training, mTOR, AMPK.

Status: Abstract Accepted (Poster Presentation)