| Exercise Induced Modulation of Thyroid Hormones in Treated Hypothyroid Patients |
| Paper ID : 1363-SPORTCONGRESS |
| Authors |
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Masoume Khosropanah * Department of Physical Education & Sport Sciences, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran |
| Abstract |
| Introduction: Thyroid hormones (T3 and T4) regulate metabolism, basal metabolic rate, and cellular function, with T3 as the biologically active form. Their synthesis is controlled by the hypothalamic, pituitary, thyroid axis. (Bansal et al., 2015) Primary hypothyroidism, a common endocrine disorder, results from insufficient hormone production and can be overt or subclinical. It is more prevalent in women and with age.(Ahmad et al., 2023) Hormonal imbalance disrupts metabolism, causing fatigue, reduced exercise tolerance, and weakness, and may persist despite hormone replacement therapy. Hypothyroidism also affects cardiovascular and musculoskeletal systems, increasing stress fracture risk. Regular exercise can modulate metabolism, improve thyroid hormone regulation, and restore physiological balance, suggesting its potential as a complementary intervention. (Gavriilidou et al., 2025) Methods: Data were synthesized from three clinical studies on adults stabilized on thyroxine therapy. In the first study, twenty men aged 30–40 years were assigned to daily one-hour exercise or non-exercise control for three months.(Bansal et al., 2015) The second study involved sixty women aged 35–45 years randomized to aerobic, resistance, combined training, or control groups, exercising three times per week for twelve weeks.(Ahmad et al., 2023) The third study included thirty women assigned to aerobic exercise or control groups with three weekly sessions over twelve weeks. (Gayar, 2023) Blood samples were collected pre and post intervention to measure T3, T4, and TSH. Results: Exercise significantly reduced serum TSH and increased T3 and T4 compared to baseline, while control groups showed no changes. Combined or aerobic training produced the most pronounced TSH reduction, highlighting the modulatory effect of structured exercise. Conclusion: Structured physical activity improves thyroid hormone profiles in treated hypothyroid patients. Both aerobic and combined training are beneficial, with combined training showing the greatest effect on TSH. Exercise can serve as a complementary strategy alongside hormone therapy to optimize thyroid function. |
| Keywords |
| Hypothyroidism, Thyroid hormones, TSH, T3, T4, Aerobic and resistance training |
| Status: Abstract Accepted (Poster Presentation) |
