| Comparative Effects of Intensity and Volume-Matched Voluntary versus Forced Exercise on Hippocampal BDNF and Spatial Memory in Male Rats |
| Paper ID : 1389-SPORTCONGRESS |
| Authors |
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Mohammad Yousefzadeh *1, Elham Azimzadeh2, Rana Fayazmilani2 1Shahid beheshti university 2shahid beheshti university |
| Abstract |
| Introduction: The hippocampus is crucial for spatial learning and memory, with brain-derived neurotrophic factor (BDNF) playing a key role in synaptic plasticity. This study compared the effects of voluntary and forced exercise, matched for intensity and volume, on hippocampal BDNF levels and spatial memory in male rats during developmental stages. Methods: 30 male Wistar rats were randomly assigned to three groups (n=10 per group): control, voluntary exercise, and forced exercise. Exercise interventions were conducted from postnatal day 28 to 49 (3 weeks). The exercise volume was completely matched between voluntary and forced exercise groups, while exercise intensity was closely matched to the extent possible. Spatial memory was assessed using the Morris water maze at three time points: post-intervention (day 51), after 30-day detraining (day 81), and during adulthood (day 83). Hippocampal BDNF levels were measured using ELISA. Results: Both exercise groups showed significant increases in hippocampal BDNF compared to controls (P=0.001). The forced exercise group demonstrated an 85% increase in BDNF, while the voluntary group showed a 58% increase. Spatial memory performance was significantly enhanced in both exercise groups compared to controls at all testing time points (P<0.01), with no significant differences between the two exercise modalities in most measures. Conclusion: When exercise parameters including intensity and volume are maintained at similar levels, both voluntary and forced exercise during the pre-pubertal period significantly enhance hippocampal BDNF levels and spatial memory, with effects persisting through detraining and into adulthood. The comparable outcomes between exercise modalities suggest that the physiological stimulus of exercise, rather than the voluntary or forced nature of the activity, is the primary factor mediating cognitive benefits. |
| Keywords |
| Exercise Intensity, BDNF, Spatial Memory, Voluntary Exercise, Forced Exercise, Hippocampus |
| Status: Abstract Accepted (Poster Presentation) |
