| The Effect of Eight Weeks of Moderate-Intensity Aerobic Exercise on the Stress oxidative in the Hippocampus of Epileptic Rats |
| Paper ID : 1431-SPORTCONGRESS |
| Authors |
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Amir Hossein Saffar Kohneh Quchan1, محمدرضا کردی *2, صباح رضاقلی3, رضا نوری4 1Assistant Professor 2استاد فیزیولوژی ورزشی دانشگاه تهران 3دانشجو دکتری فیزیولوژی ورزشی دانشگاه تهران 4دانشیار دانشگاه تهران |
| Abstract |
| Introduction: Epilepsy is one of the most common neurological disorders and ranks fifth in prevalence among neurological diseases. Globally, it affects nearly 50 million people. Since epilepsy is not a single disease but rather a spectrum of complex neurological conditions, there is no universally accepted definition. One classification is based on the affected brain region, with temporal lobe epilepsy (TLE) being the most common form(1). Oxidative stress is a critical factor in exacerbating epilepsy, neuronal hyperexcitability, and increased seizure frequency. This study aimed to investigate the effects of aerobic exercise on hippocampal malondialdehyde (MDA) levels and catalase (CAT) enzyme activity in rats with epilepsy. Methods: Thirty-two male Wistar rats (4–6 weeks old) were divided into four groups: healthy control, sham, epilepsy, and epilepsy + aerobic exercise. Epilepsy was induced via intrahippocampal kainic acid injection. Rats exhibited the first seizure symptoms 30 minutes post-injection(2).Rats underwent aerobic exercise (40 minutes per session, 5 days/week) for 8 weeks. Forty-eight hours after the final exercise session, rats were anesthetized with ketamine and xylazine, and hippocampal tissue was extracted. Catalase (CAT) activity and malondialdehyde (MDA) levels were measured using ELISA. Results: Aerobic exercise significantly reduced hippocampal MDA levels (P=0.007) and CAT enzyme activity (P=0.02) in epileptic rats. Conclusion: Eight weeks of regular exercise can lead to a reduction in lipid peroxidation and an increase in the antioxidant enzyme CAT in the hippocampus. This improvement in antioxidant status was associated with a decrease in the number of seizures. |
| Keywords |
| Oxidative stress, Seizure, Regular exercise, Lipid peroxidation |
| Status: Abstract Accepted (Oral Presentation) |
