| IDENTIFICATION OF SERUM METABOLITES AFFECTING MARATHON AND ULTRAMARATHON PERFORMANCE |
| Paper ID : 1475-SPORTCONGRESS |
| Authors |
|
mansoureh karimi * University of Gonbad Kavoss, Iran. |
| Abstract |
| As one of the most important events of the Olympic Games, marathon is popular among people all over the world. However, in recent years, irrational exercise has led to problems such as immune system damage, hyponatremia, abnormal liver and kidney function, gastrointestinal dysfunction and even sudden death, which have cast an unpleasant shadow on this sport. Usually, after runners complete a full marathon race, their skeletal muscles, myocardium, liver and other tissues face increased free radical production, lipid peroxidation and impaired ion and energy metabolism, leading to exercise-induced fatigue. On the other hand, advances in mass spectrometry (MS) over the past decade have allowed researchers to use targeted and untargeted metabolomics to better understand the metabolic response to intense, prolonged exercise. These studies have shown that intense exercise lasting two hours or more induces extensive changes in hundreds of metabolites, particularly those from the lipid biochemical pathway. However, most of these studies have been laboratory-based with relatively small numbers of study participants and recovery blood samples, and few have compared responses based on competition performance or fitness level. In support of this, Lewis et al. (2010) observed a decrease in glucogenic amino acids and an increase in metabolites related to lipolysis and ketone body production, and these findings have been confirmed in more recent studies using improved mass spectrometry technology (metabolomics). Post-race plasma glycerol concentrations were highest among runners with higher relative(VO2max) compared with those with lower aerobic capacity. These data support higher levels of lipolysis in athletes who had trained following intense exercise. The growing interest of researchers in metabolomics in exercise is due to the ability of metabolomics to simultaneously characterize multiple metabolites in multiple biological samples (such as saliva, urine, and sweat) in non-invasive ways to obtain a clear molecular picture of the impact of exercise. |
| Keywords |
| Maraton, Ultra- Maraton, Metabolomics |
| Status: Abstract Accepted (Poster Presentation) |
