| The Effect of Six Weeks of High-Intensity Interval Training (HIIT) on Resistin, ZAG, and Interleukin-6 Levels in Adipose Tissue of Male Rats with Type 2 Diabetes |
| Paper ID : 1515-SPORTCONGRESS |
| Authors |
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Ali Mansouri1, Parisa Pournemati *2, Rahman soori3 1Department of Exercise Physiology, Faculty of Sport Sciences and Health, University of Tehran 2Assistant Professor of the Exercise Physiology department, faculty of Sport sciences and Health, University of Tehran, Tehran, Iran, 3Professor of the Department of Exercise Physiology, Faculty of Sport Sciences and Health, University of Tehran |
| Abstract |
| Introduction: Type2diabetes(T2D) is a significant health concern characterized by insulin resistance, a sedentary lifestyle, and chronic, low-grade inflammation. This inflammation is often associated with elevated levels of pro-inflammatory adipokines such as Resistin and Interleukin-6(IL-6), and reduced levels of anti-inflammatory markers like Zinc-Alpha2-Glycoprotein(ZAG). HIIT is recognized as a time-efficient, non-pharmacological strategy that may help manage T2D by improving inflammation and insulin sensitivity. Methods: 24 male Wistar rats (8 weeks,220±20gr)were obtained and, following a week of acclimatization,were randomly assigned to 4groups:healthy control(C),one-week diabetes(D-1W),diabetic control(D-6W),and diabetic+exercise(D+E).Diabetes was induced through intraperitoneal injection of nicotinamide(110mg/kg) and streptozotocin(STZ)(55mg/kg).The D+E group performed the HIIT protocol for 6weeks (3sessions/week) on a treadmill. The exercise intervention included 6-10 repetitions of one-minute intervals at 70–110%VO₂max, followed by two minutes of active rest at 40–50%VO₂max. Tissue samples were collected from the adipose tissue 48 hours after the last exercise session. Data analysis was performed usingANOVA. Results:The induction of diabetes resulted in significant changes in adipokine levels,including increased Resistin and IL-6 and decreased ZAG in the adipose tissue(p < 0.05).Although the six-week HIIT program led to observed changes in these markers in the D+Egroup, the comparison between the D+Egroup and the D-6W group showed that the changes in Resistin(p = 0.474),IL-6(p = 0.1092),and ZAG(p = 0.4099) were not statistically significant. The general trend of the findings, however, suggested a reduction in the inflammatory markers Resistin and IL-6, and an increase in ZAG, indicating a potential positive impact on insulin resistance. Conclusion:The results suggest that 6 weeks of HIIT can influence inflammatory markers and insulin resistance, even if the observed changes were not statistically significant in present study. The lack of statistical significance implies that the effectiveness of HIIT may be dependent on variables such as the duration and intensity of the exercise and the initial metabolic state of the subjects. |
| Keywords |
| HIIT, resistin, interleukin-6, ZAG, type 2 diabetes |
| Status: Abstract Accepted (Oral Presentation) |
