| The Effect of the Eighth Week of Exercise on the Expression of The NF-KB Gene in the Heart Tissue of Aged Rats |
| Paper ID : 1568-SPORTCONGRESS |
| Authors |
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Amir Hosein Shahalvand, Roghayyeh Afroundeh *, Sajjad Ramezani Department of Exercise Physiology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran |
| Abstract |
| Introduction: Aging is an inevitable process that increases inflammation and contributes to cardiovascular disease. The present study aimed to investigate the effect of 8 weeks of intense interval training on the NFKB gene in the heart tissue of aged rats. Methods: In this experimental study, 14 elderly female rats over 14 months of age, with an average weight of 270-320 grams, were purchased from the Laboratory Animal Breeding and Reproduction Center of Baqiyatallah University and kept in the Exercise Physiology Laboratory of this university unit for one week for adaptation. Subsequently, the elderly female rats were randomly divided into two groups of 7. The training protocol of the present study was as follows: HIIT groups were performed with an intensity of 85 to 110% of VO2max, which is equivalent to 7 1-minute efforts and a speed of 31 m/min and active rest between intervals with 6 efforts and a speed of 15 m/min in the first week, which gradually increased by an average of 2 m/min per week to 10 1-minute efforts at a speed of 45 m/min and active rest with 9 1-minute efforts (between intervals) at a speed of 23 m/min in the eighth week. 48 hours after the last training session, the heart tissue was removed after complete anesthesia. The expression levels of the cardiac NF-kB gene were measured by real-time PCR. The independent t-test was used in SPSS 21 software for data analysis (p<0.05). Results: The results of the present study showed that HIIT training reduced the expression of the pro-inflammatory marker NF-kB (t = -3.922, P = 0.003) in heart tissue of aged mice. Conclusion: Overall, the study's results suggest that HIIT training can serve as a preventive measure against cardiovascular disease in the elderly by reducing inflammatory markers in heart tissue. |
| Keywords |
| High-intensity interval training, NF-kB, elderly, heart |
| Status: Abstract Accepted (Poster Presentation) |
