| Acute Effects of the low intensity Resistance Training on Classical Mitophagy Pathway in Aging |
| Paper ID : 1606-SPORTCONGRESS |
| Authors |
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Reyhaneh Ijadi Bajestani *1, Mohammad Reza Kordi2, Parisa Pournemati3 1Exercise physiology department, Faculty of Sport sciences and Health University of Tehran 2Professor of exercise physiology department, Faculty of Sport sciences and Health University of Tehran 3Assistant Professor of exercise physiology department, Faculty of Sport sciences and Health University of Tehran |
| Abstract |
| Introduction: Resistance training is one of the most important treatment for mitigating the loss of skeletal muscle mass associated with aging a condition termed sarcopenia. Apoptosis is a key mechanism underlying skeletal muscle atrophy, through release of cytochrome c into the cytosol. This process results from impaired mitophagy, which represent an important aspect of mitochondrial dysfunction-a hallmark of aging(1). Methods: This study measured the effect of a single session of resistance training on the classical mitophagy pathway (PINK/Parkin) and LC3B-II levels within the gastrocnemius muscle of aged Wistar rats (19 months old). six aged male Wistar rats were randomly divided into control (CON) and resistance training (RT) groups. RT group underwent ladder climbing with 25% of body weight for three set with ten climbing repetition that each one involved 8-12 stairs. Skeletal muscle samples were harvested for western blotting PINK, Parkin and LC3B-II, histological analysis (H&E staining), and TUNEL assay. Results: according to our data there were no significantly changes in the expression of the assessed proteins, DNA fragmentation and myofiber cross-sectional area. Conclusion: While our results were not statistically significant, the findings suggest that these markers may be time-dependent or influenced by differences in the training protocol especially exercise intensities. Future studies required to investigate these aspects in detail(2, 3). |
| Keywords |
| Mitophagy, Resistance training, Aging, Apoptosis |
| Status: Abstract Accepted (Oral Presentation) |
