| Effect of Combined Exercise Training on Biomarkers of Inflammation in Older People: A Systematic Review and Meta-Analysis |
| Paper ID : 1614-SPORTCONGRESS |
| Authors |
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محمدعلی امینی *1, سید مرتضی طیبی2, دیاکو حیدری3 1دانشجوی دکترا فیزیولوژی ورزشی ، گروه فیزیولوژی ورزشی ، دانشکده تربیت بدنی و علوم ورزشی ، دانشگاه علامه طباطبائی ، تهران ، ایران 2دانشیار فیزیولوژی ورزشی ، گروه فیزیولوژی ورزشی ، دانشکده تربیت بدنی و علوم ورزشی ، دانشگاه علامه طباطبائی ، تهران ، ایران 3کارشناسی ارشد فیزیولوژی ورزشی ، گروه فیزیولوژی ورزشی ، دانشکده تربیت بدنی و علوم ورزشی ، دانشگاه علامه طباطبائی ، تهران ، ایران |
| Abstract |
| Introduction: Inflammaging, a defining feature of aging, reflects a chronic state of low-grade inflammation driven by persistently elevated levels of inflammatory biomarkers. Exercise stands out as a widely recognized intervention to counteract the health declines associated with aging . Regular physical activity holds potential as an anti-inflammatory tool for older adults. Studies have demonstrated that exercise can lower circulating levels of key inflammatory markers, including IL-6, TNF-α, and CRP. This systematic review and meta-analysis aims to evaluate the effects of combined exercise training on key inflammatory markers—IL-6, TNF-α, CRP, and adiponectin in older adults. While exercise is broadly acknowledged for its anti-inflammatory properties, questions remain about whether combined training offers superior benefits compared to single-modality approaches. Methods: The current literature was searched via PubMed, Scopus and Web of Science to identify controlled clinical trials in English. Sixteen articles met the inclusion criteria. The mean difference (MD) or Standardized mean difference (SMD) with 95% confidence intervals (CIs) and the overall effect size were calculated for all comparisons. The PEDro scale was used to evaluate the quality of the articles. Results: The findings indicated that combined exercise training improved inflammatory markers in older adults: IL-6 (mean difference = 0.275, Z = 2.955, P = 0.003), CRP (mean difference = 0.468, Z = 2.003, P = 0.045), TNF-α (mean difference = 0.140, Z = 2.192, P = 0.028), and other inflammatory markers (Standardized mean difference = 0.346, Z = 3.041, P = 0.002). Conclusion: This systematic review and meta-analysis revealed that older individuals can improve their inflammatory marker levels by participating in combined exercise training programs. Combined exercise training can be a safe mode of exercise for older adults. Integrating structured combined exercise into public health guidelines is therefore critical as a viable approach to enhance general well-being and mitigate systemic inflammation. |
| Keywords |
| Combined exercise training; Inflammatory markers; Older adults. |
| Status: Abstract Accepted (Poster Presentation) |
