| Interval Resistance Training as a Multi-Modal Therapeutic Strategy: Simultaneous Modulation of Asprosin, Pro-Inflammatory Cytokines, and Body Composition in Men with Obesity |
| Paper ID : 1691-SPORTCONGRESS |
| Authors |
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Mohammad Jahangiri *1, Shahnaz Shahrbanian2 1Department of Sport Science, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran 2Department of Sport Science, Faculty of Humanities, Tarbiat Modares University, Tehran |
| Abstract |
| Abstract Introduction: Obesity represents a global health epidemic with serious metabolic and inflammatory consequences. Evidence demonstrates that resistance training (RT) effectively modulates adipocytokines and pro-inflammatory markers through non-pharmacological mechanisms. However, comparative effectiveness of different RT protocols on multiple biomarker pathways remains insufficiently characterized. This study compared the effects of 12 weeks of three resistance training modalities—traditional, circular, and interval—on asprosin (a novel adipocytokine), pro-inflammatory markers (interleukin-6 [IL-6] and tumor necrosis factor-alpha [TNF-α]), and body composition parameters in sedentary men with obesity. Methods: Forty-four sedentary men with obesity were randomly assigned to four groups: traditional RT (n=11), circular RT (n=11), interval RT (n=11), or control (n=11). All intervention groups completed 12 weeks of structured resistance training. Asprosin, IL-6, and TNF-α were quantified using commercial ELISA kits. Body composition parameters included body mass, body mass index, percent body fat, and waist-to-hip ratio. Mixed-design ANOVA with repeated measures assessed between-group and within-group changes. Results: Significant training×time interactions were observed for asprosin (F(1,40)=13353.03, P=0.001, ES=0.99), IL-6 (F(1,40)=2423.69, P=0.001, ES=0.98), and TNF-α (F(1,40)=2212.35, P=0.001, ES=0.98). All RT modalities significantly reduced asprosin, IL-6, and TNF-α compared to control (P≤0.007). Notably, interval RT demonstrated superior effects on asprosin reduction and body composition improvement (ES=0.633–0.786). Regarding pro-inflammatory markers, interval RT significantly outperformed circular RT in IL-6 reduction; however, TNF-α reductions were comparable across all three RT modalities. Conclusion: Resistance training, particularly interval protocols, effectively modulates multiple metabolic and inflammatory pathways simultaneously while improving body composition. These findings support RT—especially interval-based approaches—as a comprehensive, non-pharmacological therapeutic strategy for managing obesity and associated metabolic dysfunction. |
| Keywords |
| Keywords: Exercise, Adipocytokines, Adipose tissue, Body composition, Obesity |
| Status: Abstract Accepted (Oral Presentation) |
