| The Effect of Aerobic Training on PGC-1α and FNDC5 Gene Expression in the Gastrocnemius Muscle of Middle-Aged Male Wistar Rats |
| Paper ID : 1700-SPORTCONGRESS |
| Authors |
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sepideh akradiekhtesar *1, hamidreza norouzi2, Ali Ghasemian2 1Master's student in Exercise Physiology, Department of Sports Sciences, Faculty of Humanities, University of Zanjan, Zanjan, Iran 2Department of Sports Sciences, Faculty of Humanities, University of Zanjan, Zanjan, Iran |
| Abstract |
| Abstract The present study aimed to investigate the effect of regular aerobic training on the expression of PGC-1α and FNDC5 genes in the gastrocnemius muscle of middle-aged male Wistar rats. Twelve middle-aged rats (12–14 months old) were randomly divided into control and training groups. The training group performed an aerobic exercise protocol on a treadmill for 6 weeks, 5 days per week, at an intensity of 60–75% VO₂max. Forty-eight hours after the last training session, gastrocnemius muscle samples were collected, and the expression levels of PGC-1α and FNDC5 genes were measured using real-time PCR. The results showed that aerobic training significantly increased the expression of PGC-1α and FNDC5 genes in the gastrocnemius muscle of middle-aged rats compared to the control group (P < 0.05). Moreover, a positive correlation was observed between the expression levels of PGC-1α and FNDC5. In conclusion, these findings suggest that regular aerobic exercise may enhance mitochondrial function and metabolic adaptations in skeletal muscle during middle age through the activation of the PGC-1α–FNDC5 signaling pathway. |
| Keywords |
| Aerobic training; PGC-1α; FNDC5; Gastrocnemius muscle; Middle-aged rats; Gene expression; Mitochondrial function |
| Status: Abstract Accepted (Poster Presentation) |
