| The effect of high-intensity interval training on insulin resistance, serum levels, and irisin gene expression in subcutaneous adipose tissue of type 2 diabetic wistar rats |
| Paper ID : 1705-SPORTCONGRESS (R1) |
| Authors |
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Seyyed amirhossein Mortazavu *1, nasrin ramezani2 1ندارم 2Department of Sport Physiology, Faculty of Sport Sciences, Alzahra University, Tehran, Iran |
| Abstract |
| Introduction: Diabetes is the most common endocrine disease in the world, which is treated by various methods such as physical activity. The aim of the present study was to determine the effect of high-intensity interval training on serum glucose, insulin, insulin resistance index, irisin, and its gene expression in subcutaneous adipose tissue of type 2 diabetic wistar rats. Methods: Twenty male Wistar rats (8-10 weeks old, weighing 250-270 g) were selected and randomly divided into two diabetic control and diabetic training groups. The experimental group performed high-intensity exercise for 4 weeks, 5 days a week, for 10 minutes in 1-minute intervals at a speed of 30-40 m/min (equivalent to 75-95% of maximum oxygen consumption). 48 hours after the last training session and after 12 hours of fasting, glucose and insulin levels, insulin resistance index, serum levels, and irisin gene expression in subcutaneous adipose tissue were measured. Data were analyzed using independent t-test. Results: The results showed that 4 weeks of high-intensity interval training reduced serum glucose levels and insulin resistance index (p=0.001) and significantly increased serum levels (p=0.001) and irisin gene expression (p=0.004) in subcutaneous adipose tissue of the training group compared to the control group. Conclusion: High-intensity interval training can reduce serum glucose levels and insulin resistance index in type 2 diabetic mice and increase serum levels and irisin gene expression in adipose tissue. Therefore, this type of training can be used to reduce the complications of type 2 diabetes, in consultation with a doctor. |
| Keywords |
| Keywords: High-intensity interval training, type 2 diabetes, irisin, subcutaneous adipose tissue. |
| Status: Abstract Accepted (Poster Presentation) |
